Phytosterols are structural homologs of cholesterol that occur naturally in many plant foods. Over 30 years of research and 40 clinical trials suggest that phytosterols provide significant support for healthy lipid profiles. Well-established benefits of phytosterols on lipid balance stem primarily from competition with cholesterol for occupancy in micelles, particles that carry cholesterol across the intestinal epithelium into the systemic circulation. Through this mechanism, phytosterols promote excretion of cholesterol in the form of bile acids. Research indicates that the pine-derived phytosterols offered in this formula are comparable to phytosterols from other sources. Bergamot is a citrus fruit containing two newly discovered derivatives of the flavonoids hesperidin and naringenin. These compounds are naturally conjugated to a moiety known as hydroxymethylglutarate (HMG). In the liver, this unique molecule binds and modulates an enzyme known as HMG CoA reductase, which plays a central role in lipid biosynthesis. These unique compounds also target enzymes, transcription factors and genes involved in lipid metabolism. In a separate study of 80 subjects, 150 mg of flavonoids from Bergavit 40 bergamot extract supported healthy lipid and glucose profiles over a 6-month period. Berberine supports cardiometabolic health through a variety of mechanisms, including support for glucose and lipid metabolism. Preclinical data suggest that berberine may have antioxidant activity and favorable effects on cytokine production. In a randomized, placebo-controlled trial involving 116 subjects, berberine provided statistically significant support for glucose and lipid metabolism. It also helps maintain endothelial function, potentially by promoting healthy vascular cell adhesion molecule-1 (VCAM-1) expression and healthy iNOS activity.
Product Dimensions:4.5 x 2.5 x 2.5 inches; 4.8 Ounces Date First Available:January 30, 2012 Manufacturer:Pure Encapsulations ASIN:B0096029I6
Lipid Metabolism Support: The flavonoids, hesperidin and naringenin found in Bergamot, target enzymes, transcription factors and genes involved in healthy lipid metabolism. Healthy Lipid Support: Several studies show phytosterols and bergamot extract support already healthy cholesterol.* Pure Quality: Our supplements are made with only premium ingredients sourced from trusted suppliers and guided by our nutritional experts, then carefully manufactured and tested to verify their potency and purity. Pure Difference: What makes us different isn't just our process or what goes into our supplements -- what we leave out matters, too. Pure Encapsulations products are FREE FROM wheat, eggs, tree nuts & peanuts, gluten, artificial colors, flavors & sweeteners, coatings and shellacs, GMOs, and unnecessary binders, fillers & preservatives.